Which drugs should be avoided when eating grapefruit?

Sweet and sour grapefruit, in fact, there are many drug interactions.

Many people know that grapefruit should be avoided when taking certain western drugs, but they may not know that grapefruit contains similar ingredients that can have the same effect.

Causes of interaction

Most of all, they are rich in “furan coumarin”, which inhibits the enzymes used by the liver to metabolize certain drugs, prolonging the time for drug metabolism in the body, and increasing the concentration of drugs in the blood. As a result, adverse reactions such as taking an overdose of drugs occur.

Examples of drug-food action with grapefruit

For example, it is common to take a certain type of hypertension drugs (calcium channel blockers), when eating too many grapefruit or grapefruit, so that the impact of hypertension drug metabolism, it may be too low blood pressure phenomenon, have to be more careful.

In addition, there are many people who are taking hypolipidemic drugs because of high blood lipids. You might not have expected that because you ate more grapefruit, the drug concentration in the blood would be greatly increased, resulting in rhabdomyolysis. Like muscle soreness and reddish brown urine.

Also have because a few disease take anticoagulant drug patient for a long time, also need to be especially careful, also can because grapefruit and affect drug metabolism, the effect that causes anticoagulant greatly increases, produce haemorrhage thereby the phenomenon that does not stop.

Drugs that may interact with grapefruit

Blood pressure lowering drug

  • Felodipine
  • Nifedipine
  • Verapamil
  • Amlodipine

Cholesterol-lowering drugs

  • Atorvastatin
  • Lovastatin
  • Simvastatin


  • Warfarin

Antiarrhythmic drug

  • Amiodarone


  • Diazepam
  • Midazolam
  • Triazo
  • Buspirone


  • Cyclospor

Antiepileptic drugs

  • Carbamazepine

These drugs may interact with grapefruit, in addition to our forms of anticoagulants, many patients with cardiovascular disease, the type of drugs often used, it is possible to interact.

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