6 habits can lead to poor drug efficacy

Some foods, if eaten with drugs, can affect the efficacy of the drug. The correct posture for taking the medicine is “standing” or “sitting position”. Do not lie down immediately after taking the medicine.

Getting sick and taking medicine is a common occurrence in life. Most people take it for granted that it is generally believed that medicine can only cure if it is eaten.

But in fact, things are not so simple, so that drugs have a certain intensity of pharmacological effects on the body, there are many studies and precautions.

If you take the medicine in the wrong way, it will affect the efficacy of the drug and even cause harm to the body.

The factors that affect the efficacy of a drug in the body are not only its own ingredients, but also many seemingly insignificant details, and these easily overlooked details often determine the efficacy of the drug.

  • Why is it that the right medicine is not always improved?
  • Why is it that the medicine is right, but the medicine does not work, but it has brought many adverse reactions to the body?

This is because the factors that affect the efficacy of the drug in the body are not only its own ingredients, but also the factors such as the time, posture, water intake, and physical and mental state of the patient taking the medicine. These seemingly insignificant small details often have a major impact on the efficacy of drugs in the body.


Mental health

Physical and mental fatigue does not affect the absorption of the drug, but it will affect the efficacy.

During the illness, the body appears uncomfortable symptoms, which often affects the mood of the person. In the process of taking the medicine, it is necessary to actively face it and think more about it.

Because the body’s process of restoring health is not only due to the action of drugs, but also the regulation of neurohumoral fluid.

When we are happy, the brain will secrete some substances to help the body strengthen its resistance.

It has also been found clinically that those who can effectively regulate their emotions can better cure the disease than those who cannot adjust their emotions.

Time to take the medicine.

General instructions do not specifically indicate the time of oral medication, half an hour after meals can be taken. However, some drugs need to be taken at certain times, and there is an hour between traditional Chinese medicine and western medicine.

Taking medicine before meals means taking medicine on an empty stomach. Antacid drugs and drugs to treat gastritis, such as aluminum hydroxide, colloidal bismuth pectin, as well as gastrointestinal antispasmodic and gastric power drugs need to be taken before meals, can enhance the efficacy. Trypsin and lactozyme should also be taken before meals. Some antimicrobial drugs also need to be taken before meals.

Hypoglycemic drugs, such as acarbose, are taken with the first bite of rice to lower blood sugar levels. Taking the weight-loss drug orlistat during meals reduces the absorption of fat.

Sedative and hypnotic drugs before bedtime usually need to be taken half an hour before going to bed.

Pay attention to drinking water.

General oral dosage form of drugs, with 200 ml ~ 300 ml of warm boiled water can be sent to take. Water temperature should be 40 ℃ ~ 50 ℃, if too low, easy to make stomach discomfort.

Take medicine time as far as possible drink a little water, the irritant of some medicaments is very big, can cause esophagus to produce inflammation, ulcer even perforate.

Because the capsule is made of colloid, it is easy to become soft and sticky when exposed to hot water, and easy to adhere to the wall of the esophagus after taking. Therefore, take medicine to avoid the water temperature is too high, and to drink more water, generally not less than 300 ml, to ensure that the drug was sent to the stomach.

In addition, take antibacterial drugs, antipyretic, and so on to drink a lot of water.

There are also medicines that are susceptible to destruction in hot water, such as the following:

  • Digestive drugs, such as pepsin mixture, trypsin, multi-enzyme tablets, yeast tablets and so on, contain enzymes to aid digestion. Enzyme is a kind of active protein, the water temperature above 70 ℃ will make it invalid.
  • Active bacteria such as probiotics such as Bifidobacterium will be destroyed after exposure to heat.

Don’t lie down and take your pills. 

The correct posture for taking medicine is “standing” or “sitting”. Do not lie on your back immediately after taking the medicine. Stop for a moment and make use of the drug’s own gravity to make it pass through the esophagus quickly. In order to avoid detention in the esophagus, delay the role of drugs and esophageal mucosa damage. 

Lying in bed, medication may be dissolved in the esophagus so that the absorption of drugs, so that the drug can not give full play to the effect. In addition, if you take the medicine lying down, it is also easy to take the medicine into the trachea. 

But some drugs require lying down after taking them. If take gastric mucous membrane to protect agent, need to lie on the side after taking medicine. Lie down after taking certain blood pressure lowering drugs. 

If you feel that the medication is clogged in the esophagus and the condition is serious, you should go to the hospital immediately.

Eat your food carefully.

Some foods, if taken with a drug, can affect the efficacy of the drug. The main foods that react easily to drugs are the following.

  • Alcohol stimulates or suppresses the liver enzyme metabolism system after drinking. It is recommended that you do not drink alcohol while taking any medication.

Typical drugs: drinking alcohol when taking aspirin can cause acetaldehyde accumulation in the body, aggravate symptoms such as fever and systemic pain, and can easily cause liver damage.

  • Tea, coffee tea contains a large number of tannic acid, affecting the absorption of drugs. Caffeine has an exciting effect.

Typical drugs: ibuprofen stimulates gastric mucosa, caffeine in coffee stimulates gastric acid secretion, aggravating the side effects of ibuprofen on gastric mucosa.

  • Meat and dairy products contain histidine, which is converted to histamine in the body. Some drugs inhibit the breakdown of histamine, resulting in the accumulation of histamine.

Typical drugs: avoid eating foods rich in histidine, such as cheese and meat products, while taking anti-allergy drugs. Because anaphylaxis inhibits histamine breakdown.

Don’t cut off drugs

Drugs that cannot be cut off include: sustained release preparations, enteric solvents, and controlled release preparations. These preparations can release the drug at a specific time or part of the body. If the drug is opened, it will affect the efficacy of the drug.

The enteric coated tablets are protected by an enteric coating. If taken apart, the tablets will be dissolved just after entering the stomach and will not reach the intestine safely. This will not only affect the normal function of the drug, but also stimulate the gastric mucosa.

After the tablets of the sustained release and controlled release drugs are mashed, the controlled release film or the controlled release skeleton will be destroyed, and the drug is quickly released, so that the sustained release and long-acting effects are not achieved. Sometimes, this rapid release can also lead to a sudden increase in drug concentration in the body, causing drug poisoning.

In addition, when the capsule is taken apart, it loses its protective function. The bitter and irritating drugs can cause nausea and vomiting or dissolve the drug by gastric acid, and the efficacy is lowered.

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