Young age, how to get gastric cancer? Its cause, long – night and lack of sleep are important reasons.
According to a social survey conducted by renmin university of China, people in large and medium-sized cities in China generally go to bed more than an hour later than in 1978.
With the wide application of artificial intelligence and mobile Internet, young people are addicted to various electronic products and social tools such as mobile phones, WeChat, etc., the result of China sleep index survey 2018 shows that the phenomenon of staying up late will become more common, and the traditional daily routine of sunrise and sunset is being far away from real life.
Staying up late directly leads to the lack of sleep time and the disturbance of circadian biological rhythm, which then leads to the three major disturbances such as gastric motility, electrical frequency and endocrine hormone. The long-term health hazard cannot be underestimated, and gastric cancer is its most direct expression.
A study of sleep and stomach cancer at the national institutes of health confirmed that the risk of staying up late is 3.97 times higher than that of young men who don’t stay up late. A large number of epidemiological studies have shown that the basic gastric acid secretion disorder caused by diurnal biorhythm is closely related to gastrointestinal diseases such as gastroesophageal reflux disease, reflux esophagitis, chronic atrophic gastritis and gastric esophageal cancer.
Delve into its pathogenesis, gastric acid secretion, the basis of gastrointestinal mucosa epithelial cell proliferation, gastric emptying and gastric peristalsis, appetite regulation, are driven by the so-called clock genes, once the clock gene under the control of physiological balance and normal biological rhythm was changed, the gastrointestinal tract of the endocrine system, power system and electricity will be significantly affect the physiological system, we must attach great importance to this.
Stay up late, on the other hand, will directly affect the secretion of melatonin, melatonin is the body, one of the very important physiological hormone normally secreted by the pineal gland in the night and a large number of existed in peripheral organs, especially in the gastrointestinal system, via the central nervous system regulate circadian clock genes, which can promote and enhance the immune function of sleep.
In normal people, the concentration of melatonin in the gastrointestinal tract is 100 times that of their own blood level and 400 times that of the pineal gland, which proves that the gastrointestinal tract has a significant contribution to the circulating concentration of melatonin. Melatonin can affect the regeneration of the epithelial cells in the digestive tract, thus affecting its function, and even affecting the intestinal immune system and the tension of the gastrointestinal tract.
At the same time, the decrease in melatonin levels is closely related to the increase in age and disease, and staying up late inhibits the release of melatonin to increase the risk of cancer. A Canadian study showed that men who worked nights had 2.09 times the risk of colorectal cancer compared with those who never worked nights, and 1.34 times the risk of stomach cancer. Numerous animal studies have also shown that sleep rhythm disorders can directly lead to cancer.
Modern medical research shows that the basic acid level of human body is the highest at night and the lowest in the morning, following the circadian biological rhythm. Changes in biorhythm, such as international long-distance flights, night shifts and space travel, are also associated with gastrointestinal symptoms, with the binding site of melatonin showing diurnal periodic changes in the stomach.
The average frequency of dynamic eegs in healthy youth was 2.92 + 0.15 CPM at noon to 2.72 + 0.13 CPM at night, which was consistent with the biological rhythm of colon movement. This is why healthy people tend to defecate during the day, but rarely at night.
For our mental health and family happiness, please remember not to stay up too late.