Researchers in the United States have developed an oral insulin capsule that allows many patients who control their blood sugar by daily insulin injections to dramatically improve their quality of life.
According to a study in the Proceedings of the National Academy of Sciences, patients with type 1 diabetes need to be treated with foreign insulin for life because they do not produce enough insulin. Insulin injection is still the main method to control blood glucose in patients with type 1 diabetes mellitus. However, due to fear of pain, fear of needles and other reasons, many patients can not be injected once or twice a day on time, resulting in serious health impact. Although the medical community has developed oral insulin, oral insulin is difficult to prepare, easy to degrade, and difficult to absorb in the intestinal tract.
The Xinhua News Agency reports that researchers at Harvard University and the University of California at Santa Barbara recently published a paper indicating that they have developed an enteric-coated capsule. Insulin in the capsule is carried by an ionic liquid of choline and folic acid. Choline is one of the nutrients the Food and Drug Administration recommends daily; folic acid is a common ingredient in cardamom and lemon grass and is widely used as a food additive.
The capsules, which dissolve only in alkaline conditions in the small intestine, prevent insulin from being degraded by enzymes in the gastrointestinal tract, help insulin seep into the intestine, and do not trigger rejection, are easy to produce and can be stored at room temperature for two months, the researchers said. The shelf life of insulin injection is better than that of insulin injection commonly used in the market. The next step for the researchers is to carry out animal experiments.