There are three masterpieces in the history of human medicine: aspirin penicillin and diazepam. Among them, aspirin is known as the “golden oil” of drugs, it was first widely used as a painkiller in clinical, and later found that it plays an important role in inhibiting platelet aggregation and preventing thrombosis, after many years of clinical practice. Aspirin has finally established its position in the prevention and treatment of cardiovascular and cerebrovascular diseases. Before using the drug, it is generally recommended to stratify the risk of cardiovascular and cerebrovascular disease, including age, sex, blood pressure, body mass index, blood lipids, smoking, diabetes, and so on. For patients who need to take aspirin, as long as they can tolerate, no gastrointestinal bleeding, asthma attacks and other side effects, are generally recommended for a long time to take.
However, with the long-term use of drugs, some problems will arise. Aspirin has been found to be a “thief” of vitamin C in recent years. Even taking a small amount of aspirin can also make vitamin C output more than three times higher than normal, long-term drug use is easy to cause vitamin C deficiency in the body. Vitamin C plays an important role in enhancing immunity, promoting wound healing, enhancing immunity, promoting growth and development, enhancing capillary elasticity, preventing aging, preventing tumor, preventing chronic lead mercury heavy metal poisoning and so on. Therefore, timely supplementation of vitamin C is essential for patients who need to take aspirin for a long time. Other studies have shown that vitamin C in patients with cardiovascular disease also has the effect of regulating fat metabolism, reducing the content of blood cholesterol, cardiovascular disease prevention can play a positive role.
However, vitamin C in combination with certain drugs can be taboo. So there are patients who wonder if aspirin can be taken with vitamin C? Pharmacological studies have shown that both aspirin and vitamin C are acidic drugs. Salicylic acid, which is contained in aspirin, is metabolized by enzymes in the liver to produce salicylate, which is excreted mainly through the kidneys. The excretion volume is easily affected by pH value of urine. Generally in alkaline urine, salicylate excretion rate can reach 85%, in acidic urine, salicylate excretion rate is less than 5%. In theory, vitamin C has the effect of acidification of urine, aspirin and vitamin C taken at the same time, may lead to the reduction of salicylate excretion, which is easy to cause salicylate accumulation. But in fact, the human body itself has acid-base regulation function, the treatment dose of vitamin C is not enough to change urine pH, so do not worry about taking vitamin C will affect the efficacy of aspirin. If the patient still has worry, might as well take two kinds of drugs staggered time, generally two hours interval then.